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Nucleic Acids Research 2006 34(Database Issue):D664-D667; doi:10.1093/nar/gkj065
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Nucleic Acids Research, 2006, Vol. 34, Database issue D664-D667
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

AOBase: a database for antisense oligonucleotides selection and design

Xiaochen Bo, Shaoke Lou, Daochun Sun, Jing Yang and Shengqi Wang*

Beijing Institute of Radiation Medicine Beijing 100850, China

*To whom correspondence should be addressed. Tel/Fax: +86 10 68210077 932211; Email: sqwang{at}bmi.com

Received August 14, 2005. Revised October 8, 2005. Accepted October 8, 2005.

Antisense oligonucleotides (ODNs) technology is one of the important approaches for the sequence-specific knockdown of gene expression. ODNs have been used as research tools in the post-genome era, as well as new types of therapeutic agents. Since finding effective target sites within RNA is a hard work for antisense ODNs design, various experimental methods and computational approaches have been proposed. For better sharing of the experimented and published ODNs, valid and invalid ODNs reported in literatures are screened, collected and stored in AOBase. Till now, ~700 ODNs against 46 target mRNAs are contained in AOBase. Entries can be explored via TargetSearch and AOSearch web retrieval interfaces. AOBase can not only be useful in ODNs selection for gene function exploration, but also contribute to mining rules and developing algorithms for rational ODNs design. AOBase is freely accessible via http://www.bioit.org.cn/ao/aobase.

The authors wish it to be known that, in their opinion, the first three authors should be regarded as joint First Authors


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Z. J. Lu and D. H. Mathews
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