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Nucleic Acids Research 2006 34(Database Issue):D700-D704; doi:10.1093/nar/gkj030
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Nucleic Acids Research, 2006, Vol. 34, Database issue D700-D704
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org


Article

HvrBase++: a phylogenetic database for primate species

Jochen Kohl, Ingo Paulsen, Thomas Laubach, Achim Radtke and Arndt von Haeseler1,2,3,4,*

Heinrich-Heine-University Duesseldorf, Universitaetsstrasse 1 40225 Duesseldorf, Germany 1Max F. Perutz Laboratories, University of Vienna, Center for Integrative Bioinformatics Vienna Dr.-Bohr-Gasse 9/6, A-1030 Vienna, Austria 2University of Vienna Vienna, Austria 3Medical University of Vienna Vienna, Austria 4University of Veterinary Medicine Vienna Vienna, Austria

*To whom correspondence should be addressed. Tel: +43 1 4277 24007; Email: arndt.von.haeseler{at}univie.ac.at

Received August 15, 2005. Revised September 22, 2005. Accepted September 22, 2005.

HvrBase++ is the improved and extended version of HvrBase. Extensions are made by adding more population-based sequence samples from all primates including humans. The current collection comprises 13 873 hypervariable region I (HVRI) sequences and 4940 hypervariable region II (HVRII) sequences. In addition, we included 1376 complete mitochondrial genomes, 205 sequences from X-chromosomal loci and 202 sequences from autosomal chromosomes 1, 8, 11 and 16. In order to reduce the introduction of erroneous data into HvrBase++, we have developed a procedure that monitors GenBank for new versions of the current data in HvrBase++ and automatically updates the collection if necessary. For the stored sequences, supplementary information such as geographic origin, population affiliation and language of the sequence donor can be retrieved. HvrBase++ is Oracle based and easily accessible by a web interface (http://www.hvrbase.org). As a new key feature, HvrBase++ provides an interactive graphical tool to easily access data from dynamically created geographical maps.


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