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HvrBase++: a phylogenetic database for primate species
Heinrich-Heine-University Duesseldorf, Universitaetsstrasse 1 40225 Duesseldorf, Germany 1Max F. Perutz Laboratories, University of Vienna, Center for Integrative Bioinformatics Vienna Dr.-Bohr-Gasse 9/6, A-1030 Vienna, Austria 2University of Vienna Vienna, Austria 3Medical University of Vienna Vienna, Austria 4University of Veterinary Medicine Vienna Vienna, Austria
*To whom correspondence should be addressed. Tel: +43 1 4277 24007; Email: arndt.von.haeseler{at}univie.ac.at
Received August 15, 2005. Revised September 22, 2005. Accepted September 22, 2005.
HvrBase++ is the improved and extended version of HvrBase. Extensions are made by adding more population-based sequence samples from all primates including humans. The current collection comprises 13 873 hypervariable region I (HVRI) sequences and 4940 hypervariable region II (HVRII) sequences. In addition, we included 1376 complete mitochondrial genomes, 205 sequences from X-chromosomal loci and 202 sequences from autosomal chromosomes 1, 8, 11 and 16. In order to reduce the introduction of erroneous data into HvrBase++, we have developed a procedure that monitors GenBank for new versions of the current data in HvrBase++ and automatically updates the collection if necessary. For the stored sequences, supplementary information such as geographic origin, population affiliation and language of the sequence donor can be retrieved. HvrBase++ is Oracle based and easily accessible by a web interface (http://www.hvrbase.org). As a new key feature, HvrBase++ provides an interactive graphical tool to easily access data from dynamically created geographical maps.
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