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Nucleic Acids Research 2006 34(Database Issue):D86-D89; doi:10.1093/nar/gkj129
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Nucleic Acids Research, 2006, Vol. 34, Database issue D86-D89
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

DBTSS: DataBase of Human Transcription Start Sites, progress report 2006

Riu Yamashita, Yutaka Suzuki1,*, Hiroyuki Wakaguri1, Katsuki Tsuritani, Kenta Nakai and Sumio Sugano1

Human Genome Center, Institute of Medical Science, University of Tokyo 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan 1Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo 5-1-5, Kashiwanoha, Kashiwa, Chiba 277-8562, Japan

*To whom correspondence should be addressed. Tel: +81 4 7136 3607; Fax: +81 4 7136 3607; Email: ysuzuki{at}hgc.Jp

Received September 15, 2005. Revised October 21, 2005. Accepted October 21, 2005.

DBTSS was first constructed in 2002 based on precise, experimentally determined 5' end clones. Several major updates and additions have been made since the last report. First, the number of human clones has drastically increased, going from 190 964 to 1 359 000. Second, information about potential alternative promoters is presented because the number of 5' end clones is now sufficient to determine several promoters for one gene. Namely, we defined putative promoter groups by clustering transcription start sites (TSSs) separated by <500 bases. A total of 8308 human genes and 4276 mouse genes were found to have putative multiple promoters. Third, DBTSS provides detailed sequence comparisons of user-specified TSSs. Finally, we have added TSS information for zebrafish, malaria and schyzon (a red algae model organism). DBTSS is accessible at http://dbtss.hgc.jp.


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