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A new generation of JASPAR, the open-access repository for transcription factor binding site profiles
Department for Molecular Biomedical Research (DMBR), VIB—Ghent University Technologiepark 927 B-9052 Ghent (Zwijnaarde), Belgium 1Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan 2Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia Vancouver, BC, Canada 3Computational Biology Unit, Bergen Center for Computational Science, University of Bergen Thormøhlensgate 55, N-5008 Bergen, Norway
*To whom correspondence should be addressed. Tel: +47 55 84362; Fax: +47 555 84295; Email: Boris.Lenhard{at}bccs.uib.no
Received September 13, 2005. Revised October 18, 2005. Accepted October 18, 2005.
JASPAR is the most complete open-access collection of transcription factor binding site (TFBS) matrices. In this new release, JASPAR grows into a meta-database of collections of TFBS models derived by diverse approaches. We present JASPAR CORE—an expanded version of the original, non-redundant collection of annotated, high-quality matrix-based transcription factor binding profiles, JASPAR FAM—a collection of familial TFBS models and JASPAR phyloFACTS—a set of matrices computationally derived from statistically overrepresented, evolutionarily conserved regulatory region motifs from mammalian genomes. JASPAR phyloFACTS serves as a non-redundant extension to JASPAR CORE, enhancing the overall breadth of JASPAR for promoter sequence analysis. The new release of JASPAR is available at http://jaspar.genereg.net.
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors
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