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SVMHC: a server for prediction of MHC-binding peptides
Division for Simulation of Biological Systems, WSI/ZBIT, Eberhard Karls University Tübingen Sand 14, D-72076 Tübingen, Germany
*To whom correspondence should be addressed. Tel: +49 7071 29 70459; Fax: +49 7071 29 5152; Email: doennes{at}informatik.uni-tuebingen.de
Received February 14, 2006. Revised March 2, 2006. Accepted April 5, 2006.
Identification of MHC-binding peptides is a prerequisite in rational design of T-cell based peptide vaccines. During the past decade a number of computational approaches have been introduced for the prediction of MHC-binding peptides, efficiently reducing the number of candidate binders that need to be experimentally verified. Here the SVMHC server for prediction of both MHC class I and class II binding peptides is presented. SVMHC offers fast analysis of a wide range of alleles and prediction results are given in several comprehensive formats. The server can be used to find the most likely binders in a protein sequence and to investigate the effects of single nucleotide polymorphisms in terms of MHC-peptide binding. The SVMHC server is accessible at http://www-bs.informatik.uni-tuebingen.de/SVMHC/.
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