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Nucleic Acids Research 2006 34(Web Server issue):W366-W368; doi:10.1093/nar/gkl069
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© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org


Article

MicroFootPrinter: a tool for phylogenetic footprinting in prokaryotic genomes

Shane Neph and Martin Tompa*

Department of Computer Science and Engineering and Department of Genome Sciences, University of Washington Box 352350, Seattle, WA 98195-2350, USA

*To whom correspondence should be addressed. Tel: +1 206 543 9263; Fax: +1 206 543 8331; Email: tompa{at}cs.washington.edu

Received February 11, 2006. Revised February 19, 2006. Accepted March 1, 2006.

Phylogenetic footprinting is a method for the discovery of regulatory elements in a set of homologous regulatory regions, usually collected from multiple species. It does so by identifying the most conserved motifs in those homologous regions. This note describes web software that has been designed specifically for this purpose in prokaryotic genomes, making use of the phylogenetic relationships among the homologous sequences in order to make more accurate predictions. The software is called MicroFootPrinter and is available at http://bio.cs.washington.edu/software.html.


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