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MicroFootPrinter: a tool for phylogenetic footprinting in prokaryotic genomes
Department of Computer Science and Engineering and Department of Genome Sciences, University of Washington Box 352350, Seattle, WA 98195-2350, USA
*To whom correspondence should be addressed. Tel: +1 206 543 9263; Fax: +1 206 543 8331; Email: tompa{at}cs.washington.edu
Received February 11, 2006. Revised February 19, 2006. Accepted March 1, 2006.
Phylogenetic footprinting is a method for the discovery of regulatory elements in a set of homologous regulatory regions, usually collected from multiple species. It does so by identifying the most conserved motifs in those homologous regions. This note describes web software that has been designed specifically for this purpose in prokaryotic genomes, making use of the phylogenetic relationships among the homologous sequences in order to make more accurate predictions. The software is called MicroFootPrinter and is available at http://bio.cs.washington.edu/software.html.
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