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SNPmasker: automatic masking of SNPs and repeats across eukaryotic genomes
1 Department of Bioinformatics, University of Tartu Estonia 2 Estonian Biocentre, Tartu Estonia
*To whom correspondence should be addressed. Tel: +372 7375001; Fax: +372 7420286; Email: maido.remm{at}ut.ee
Received February 14, 2006. Revised February 23, 2006. Accepted March 13, 2006.
SNPmasker is a comprehensive web interface for masking large eukaryotic genomes. The program is designed to mask SNPs from recent dbSNP database and to mask the repeats with two alternative programs. In addition to the SNP masking, we also offer population-specific substitution of SNP alleles in genomic sequence according to SNP frequencies in HapMap Phase II data. The input to SNPmasker can be defined in chromosomal coordinates or inserted as a sequence. The sequences masked by our web server are most useful as a preliminary step for different primer and probe design tasks. The service is available at http://bioinfo.ebc.ee/snpmasker/ and is free for all users.
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