Skip Navigation


Nucleic Acids Research Advance Access originally published online on May 5, 2007
Nucleic Acids Research 2007 35(11):3519-3524; doi:10.1093/nar/gkm071
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (407K) Freely available
Right arrow Screen PDF (175K) Freely available
Right arrowOA All Versions of this Article:
35/11/3519    most recent
gkm071v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Jarrous, N.
Right arrow Articles by Reiner, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jarrous, N.
Right arrow Articles by Reiner, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2007, Vol. 35, No. 11 3519-3524
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Survey and Summary

Human RNase P: a tRNA-processing enzyme and transcription factor

Nayef Jarrous* and Robert Reiner

Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel

*To whom correspondence should be addressed. Tel: 972 2 6758233; Fax: 972 2 6784010; Email: jarrous{at}md.huji.ac.il

Received January 11, 2007. Revised January 24, 2007. Accepted January 24, 2007.

Ribonuclease P (RNase P) has been hitherto well known as a catalytic ribonucleoprotein that processes the 5' leader sequence of precursor tRNA. Recent studies, however, reveal a new role for nuclear forms of RNase P in the transcription of tRNA genes by RNA polymerase (pol) III, thus linking transcription with processing in the regulation of tRNA gene expression. However, RNase P is also essential for the transcription of other small noncoding RNA genes, whose precursor transcripts are not recognized as substrates for this holoenzyme. Accordingly, RNase P can act solely as a transcription factor for pol III, a role that seems to be conserved in eukarya.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 RNAHome page
J. Hsieh and C. A. Fierke
Conformational change in the Bacillus subtilis RNase P holoenzyme-pre-tRNA complex enhances substrate affinity and limits cleavage rate
RNA, August 1, 2009; 15(8): 1565 - 1577.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
J. Hsieh, S. C. Walker, C. A. Fierke, and D. R. Engelke
Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release
RNA, February 1, 2009; 15(2): 224 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
B. K. Mohanty and S. R. Kushner
Ribonuclease P processes polycistronic tRNA transcripts in Escherichia coli independent of ribonuclease E
Nucleic Acids Res., December 3, 2007; 35(22): 7614 - 7625.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.