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Nucleic Acids Research Advance Access originally published online on July 18, 2007
Nucleic Acids Research 2007 35(15):5028-5038; doi:10.1093/nar/gkm533
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Nucleic Acids Research, 2007, Vol. 35, No. 15 5028-5038
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Molecular Biology

Interaction of estrogen receptor {alpha} with proliferating cell nuclear antigen

Jennifer R. Schultz-Norton1, Vivian A. Gabisi2, Yvonne S. Ziegler1, Ian X. McLeod3, John R. Yates3 and Ann M. Nardulli1,*

1Department of Molecular and Integrative Physiology and 2Department of Biochemistry, University of Illinois, Urbana, IL 61801 and 3Department of Cell Biology, The Scripps Institute, LaJolla, CA 92037, USA

*To whom correspondence should be addressed. Tel: +1 217 244 5679; Fax: +1 217 333 1133; Email: anardull{at}life.uiuc.edu

Received May 7, 2007. Revised June 21, 2007. Accepted June 26, 2007.

The ability of estrogen receptor {alpha} (ER{alpha}) to modulate gene expression is influenced by the recruitment of a host of co-regulatory proteins to target genes. To further understand how estrogen-responsive genes are regulated, we have isolated and identified proteins associated with ER{alpha} when it is bound to DNA containing the consensus estrogen response element (ERE). One of the proteins identified in this complex, proliferating cell nuclear antigen (PCNA), is required for DNA replication and repair. We show that PCNA interacts with ER{alpha} in the absence and in the presence of DNA, enhances the interaction of ER{alpha} with ERE-containing DNA, and associates with endogenous estrogen-responsive genes. Interestingly, rather than altering hormone responsiveness of endogenous, estrogen-responsive genes, PCNA increases the basal expression of these genes. Our studies suggest that in addition to serving as a platform for the recruitment of DNA replication and repair proteins, PCNA may serve as a platform for transcription factors involved in regulating gene expression.


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