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Nucleic Acids Research Advance Access originally published online on October 16, 2007
Nucleic Acids Research 2007 35(22):7485-7496; doi:10.1093/nar/gkm860
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Nucleic Acids Research, 2007, Vol. 35, No. 22 7485-7496
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Caloric restriction and genomic stability

Ahmad R. Heydari1, Archana Unnikrishnan1, Lisa Ventrella Lucente1 and Arlan Richardson2,*

1Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202 and 2Barshop Institute for Longevity and Aging Studies and Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245-3207, USA

* To whom correspondence should be addressed. Tel: 210-562-6140; Fax: 210-562-6110; Email: richardsona{at}uthscsa.edu

Received July 20, 2007. Revised September 21, 2007. Accepted September 26, 2007.

Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced tumors in laboratory rodents while increasing mean and maximum life spans. It has been suggested that CR extends longevity and reduces age-related pathologies by reducing the levels of DNA damage and mutations that accumulate with age. This hypothesis is attractive because the integrity of the genome is essential to a cell/organism and because it is supported by observations that both cancer and immunological defects, which increase significantly with age and are delayed by CR, are associated with changes in DNA damage and/or DNA repair. Over the last three decades, numerous laboratories have examined the effects of CR on the integrity of the genome and the ability of cells to repair DNA. The majority of studies performed indicate that the age-related increase in oxidative damage to DNA is significantly reduced by CR. Early studies suggest that CR reduces DNA damage by enhancing DNA repair. With the advent of genomic technology and our increased understanding of specific repair pathways, CR has been shown to have a significant effect on major DNA repair pathways, such as NER, BER and double-strand break repair.


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