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Nucleic Acids Research Advance Access originally published online on December 14, 2006
Nucleic Acids Research 2007 35(Database issue):D162-D164; doi:10.1093/nar/gkl994
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Nucleic Acids Research, 2007, Vol. 35, Database issue D162-D164
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

Noncoding RNAs database (ncRNAdb)

Maciej Szymanski*, Volker A. Erdmann1 and Jan Barciszewski

Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Noskowskiego 12 61-704 Poznan, Poland 1 Institute fur Chemie/Biochemie, Freie Universitat Berlin Thielallee 63, 14195 Berlin, Germany

*To whom correspondence should be addressed. Tel: +48 61 8528503; Fax: +48 61 8520532; Email: mszyman{at}ibch.poznan.pl

Received September 15, 2006. Revised October 27, 2006. Accepted October 30, 2006.

The noncoding RNA database (ncRNAdb) was created as a source of information on RNA molecules, which do not possess protein-coding capacity. It is now widely accepted that, in addition to constitutively expressed, housekeeping or infrastructural RNAs, there is a wide variety of RNAs participating in mechanisms involved in regulation of gene expression at all levels of transmission of genetic information from DNA to proteins. Noncoding RNAs' activities include chromatin structure remodeling, transcriptional and translational regulation of gene expression, modulation of protein function and regulation of subcellular distribution of RNAs as well as proteins. Noncoding transcripts have been identified in organisms belonging to all domains of life. Currently, the ncRNAdb contains >30 000 ncRNA sequences from Eukaryotes, Eubacteria and Archaea, but does not include housekeeping transcripts or microRNAs and snoRNAs for which more specialized databases are available. The contents of the database can be accessed via the WWW at http://biobases.ibch.poznan.pl/ncRNA/.


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[Abstract] [Full Text] [PDF]


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