Nucleic Acids Research, 2007, Vol. 35, Database issue D224-D228
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Articles |
New developments in the InterPro database
1 EMBL Outstation—European Bioinformatics Institute Hinxton, Cambridge, UK 2 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, UK 3 Faculty of Life Sciences and School of Computer Science, University of Manchester Manchester, UK 4 Swiss Institute for Bioinformatics Geneva, Switzerland 5 Department of Structural Biology and Bioinformatics, University of Geneva Switzerland 6 Biocomputing Unit EMBL, Heidelberg Germany 7 Wellcome Trust Centre for Human Genetics, Oxford UK 8 CNRS/INRA, Toulouse France 9 Biochemistry and Molecular Biology Department, University College London University of London, UK 10 Genomic Sciences Centre, RIKEN Yokohama Institute Suehiro-cho, Tsurumi-ku, Yokohama, Japan 11 The Institute for Genomic Research, Rockville MD, USA 12 Laboratoire de Biomètrie et Biologie Evolutive and INRIA HELIX Project University Lyon 1, France 13 Evolutionary Systems Biology Group, SRI International Menlo Park, CA, USA 14 MRC Laboratory of Molecular Biology, Cambridge UK 15 Protein Information Resource, Georgetown University Medical Center Washington, DC, USA
*To whom correspondence should be addressed. Tel: +44 1223 494 602; Fax: +44 1223 494 468; Email: mulder{at}ebi.ac.uk
Received September 5, 2006. Revised October 6, 2006. Accepted October 6, 2006.
InterPro is an integrated resource for protein families, domains and functional sites, which integrates the following protein signature databases: PROSITE, PRINTS, ProDom, Pfam, SMART, TIGRFAMs, PIRSF, SUPERFAMILY, Gene3D and PANTHER. The latter two new member databases have been integrated since the last publication in this journal. There have been several new developments in InterPro, including an additional reading field, new database links, extensions to the web interface and additional match XML files. InterPro has always provided matches to UniProtKB proteins on the website and in the match XML file on the FTP site. Additional matches to proteins in UniParc (UniProt archive) are now available for download in the new match XML files only. The latest InterPro release (13.0) contains more than 13 000 entries, covering over 78% of all proteins in UniProtKB. The database is available for text- and sequence-based searches via a webserver (http://www.ebi.ac.uk/interpro), and for download by anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro). The InterProScan search tool is now also available via a web service at http://www.ebi.ac.uk/Tools/webservices/WSInterProScan.html.
Present address: Julian Gough, Unite de Bioinformatique Structurale, Institut Pasteur, Paris, France
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