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Nucleic Acids Research Advance Access originally published online on November 10, 2006
Nucleic Acids Research 2007 35(Database issue):D358-D362; doi:10.1093/nar/gkl825
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Nucleic Acids Research, 2007, Vol. 35, Database issue D358-D362
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

STRING 7—recent developments in the integration and prediction of protein interactions

Christian von Mering1,2,*, Lars J. Jensen1, Michael Kuhn1, Samuel Chaffron1,2, Tobias Doerks1, Beate Krüger1, Berend Snel3 and Peer Bork1,4

1 European Molecular Biology Laboratory, Meyerhofstrasse 1 69117 Heidelberg, Germany 2 University of Zurich, Winterthurerstrasse 190 8057 Zurich, Switzerland 3 Utrecht University, Padualaan 8 3584 CH Utrecht, The Netherlands 4 Max-Delbrück-Centre for Molecular Medicine, Robert-Rössle-Str. 10 13092 Berlin, Germany

*To whom correspondence should be addressed. Tel: +41 44 6353147; Fax: +41 44 6356864; Email: mering{at}molbio.unizh.ch

Received September 15, 2006. Revised October 5, 2006. Accepted October 5, 2006.

Information on protein–protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational techniques. The database and online resource STRING generalizes access to protein interaction data, by integrating known and predicted interactions from a variety of sources. The underlying infrastructure includes a consistent body of completely sequenced genomes and exhaustive orthology classifications, based on which interaction evidence is transferred between organisms. Although primarily developed for protein interaction analysis, the resource has also been successfully applied to comparative genomics, phylogenetics and network studies, which are all facilitated by programmatic access to the database backend and the availability of compact download files. As of release 7, STRING has almost doubled to 373 distinct organisms, and contains more than 1.5 million proteins for which associations have been pre-computed. Novel features include AJAX-based web-navigation, inclusion of additional resources such as BioGRID, and detailed protein domain annotation. STRING is available at http://string.embl.de/

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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