Nucleic Acids Research Advance Access originally published online on November 28, 2006
Nucleic Acids Research 2007 35(Database issue):D492-D497; doi:10.1093/nar/gkl906
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Nucleic Acids Research, 2007, Vol. 35, Database issue D492-D497
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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GenomeRNAi: a database for cell-based RNAi phenotypes
German Cancer Research Center, Boveri-Group Signaling and Functional Genomics Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany
*To whom correspondence should be adddressed. Tel: +49 6221 421951; Fax: +49 6221 421959; Email: m.boutros{at}dkfz.de
Received August 15, 2006. Revised October 11, 2006. Accepted October 12, 2006.
RNA interference (RNAi) has emerged as a powerful tool to generate loss-of-function phenotypes in a variety of organisms. Combined with the sequence information of almost completely annotated genomes, RNAi technologies have opened new avenues to conduct systematic genetic screens for every annotated gene in the genome. As increasing large datasets of RNAi-induced phenotypes become available, an important challenge remains the systematic integration and annotation of functional information. Genome-wide RNAi screens have been performed both in Caenorhabditis elegans and Drosophila for a variety of phenotypes and several RNAi libraries have become available to assess phenotypes for almost every gene in the genome. These screens were performed using different types of assays from visible phenotypes to focused transcriptional readouts and provide a rich data source for functional annotation across different species. The GenomeRNAi database provides access to published RNAi phenotypes obtained from cell-based screens and maps them to their genomic locus, including possible non-specific regions. The database also gives access to sequence information of RNAi probes used in various screens. It can be searched by phenotype, by gene, by RNAi probe or by sequence and is accessible at http://rnai.dkfz.de
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  M. Gilsdorf, T. Horn, Z. Arziman, O. Pelz, E. Kiner, and M. Boutros GenomeRNAi: a database for cell-based RNAi phenotypes. 2009 update Nucleic Acids Res., November 12, 2009; (2009) gkp1038v1. [Abstract] [Full Text] [PDF]
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