Nucleic Acids Research Advance Access originally published online on June 18, 2007
Nucleic Acids Research 2007 35(Web Server issue):W169-W175; doi:10.1093/nar/gkm415
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Nucleic Acids Research, 2007, Vol. 35, No. suppl_2 W169-W175
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists
1Laboratory of Immunopathogenesis and Bioinformatics, 2Advanced Biomedical Computing Center, 3Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, MD 21702, USA, 4Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA, 5Bioinformatics and Scientific IT Program, NIAID Office of Technology Information Systems, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
*To whom correspondence should be addressed. Tel: +1-301-846-7114; Fax: 301-846-7672; Email: rlempicki{at}mail.nih.gov
Received January 22, 2007. Revised April 14, 2007. Accepted May 6, 2007.
All tools in the DAVID Bioinformatics Resources aim to provide functional interpretation of large lists of genes derived from genomic studies. The newly updated DAVID Bioinformatics Resources consists of the DAVID Knowledgebase and five integrated, web-based functional annotation tool suites: the DAVID Gene Functional Classification Tool, the DAVID Functional Annotation Tool, the DAVID Gene ID Conversion Tool, the DAVID Gene Name Viewer and the DAVID NIAID Pathogen Genome Browser. The expanded DAVID Knowledgebase now integrates almost all major and well-known public bioinformatics resources centralized by the DAVID Gene Concept, a single-linkage method to agglomerate tens of millions of diverse gene/protein identifiers and annotation terms from a variety of public bioinformatics databases. For any uploaded gene list, the DAVID Resources now provides not only the typical gene-term enrichment analysis, but also new tools and functions that allow users to condense large gene lists into gene functional groups, convert between gene/protein identifiers, visualize many-genes-to-many-terms relationships, cluster redundant and heterogeneous terms into groups, search for interesting and related genes or terms, dynamically view genes from their lists on bio-pathways and more. With DAVID (http://david.niaid.nih.gov), investigators gain more power to interpret the biological mechanisms associated with large gene lists.
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.
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