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Nucleic Acids Research Advance Access originally published online on June 12, 2007
Nucleic Acids Research 2007 35(Web Server issue):W460-W464; doi:10.1093/nar/gkm363
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Nucleic Acids Research, 2007, Vol. 35, No. suppl_2 W460-W464
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

PrDOS: prediction of disordered protein regions from amino acid sequence

Takashi Ishida1,* and Kengo Kinoshita1,2

1Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan and 2Structure and Function of Biomolecules, SORST JST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

*To whom correspondence should be addressed. Tel: +81-3-5449-5131; Fax: +81-3-5449-5133; Email: t-ishida{at}hgc.jp

Received January 31, 2007. Revised April 11, 2007. Accepted April 25, 2007.

PrDOS is a server that predicts the disordered regions of a protein from its amino acid sequence (http://prdos.hgc.jp). The server accepts a single protein amino acid sequence, in either plain text or FASTA format. The prediction system is composed of two predictors: a predictor based on local amino acid sequence information and one based on template proteins. The server combines the results of the two predictors and returns a two-state prediction (order/disorder) and a disorder probability for each residue. The prediction results are sent by e-mail, and the server also provides a web-interface to check the results.


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