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Nucleic Acids Research Advance Access originally published online on September 23, 2008
Nucleic Acids Research 2008 36(18):5970-5982; doi:10.1093/nar/gkn594
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Nucleic Acids Research, 2008, Vol. 36, No. 18 5970-5982
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Genomics

Megasatellites: a peculiar class of giant minisatellites in genes involved in cell adhesion and pathogenicity in Candida glabrata

Agnès Thierry1, Christiane Bouchier2, Bernard Dujon1 and Guy-Franck Richard1,*

1Institut Pasteur, Unité de Génétique Moléculaire des Levures; CNRS, URA2171; Université Pierre et Marie Curie, UFR 927; 25 rue du Dr Roux and 2Institut Pasteur, Plate-Forme 1-Génomique; 28 rue du Dr Roux, F-75015 Paris, France

*To whom correspondence should be addressed. Tel: +33 1 40 61 34 54; Fax: +33 1 40 61 34 56; Email: gfrichar{at}pasteur.fr

Received July 1, 2008. Revised August 26, 2008. Accepted September 3, 2008.

Minisatellites are DNA tandem repeats that are found in all sequenced genomes. In the yeast Saccharomyces cerevisiae, they are frequently encountered in genes encoding cell wall proteins. Minisatellites present in the completely sequenced genome of the pathogenic yeast Candida glabrata were similarly analyzed, and two new types of minisatellites were discovered: minisatellites that are composed of two different intermingled repeats (called compound minisatellites), and minisatellites containing unusually long repeated motifs (126–429 bp). These long repeat minisatellites may reach unusual length for such elements (up to 10 kb). Due to these peculiar properties, they have been named ‘megasatellites’. They are found essentially in genes involved in cell–cell adhesion, and could therefore be involved in the ability of this opportunistic pathogen to colonize the human host. In addition to megasatellites, found in large paralogous gene families, there are 93 minisatellites with simple shorter motifs, comparable to those found in S. cerevisiae. Most of the time, these minisatellites are not conserved between C. glabrata and S. cerevisiae, although their host genes are well conserved, raising the question of an active mechanism creating minisatellites de novo in hemiascomycetes.


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