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Nucleic Acids Research Advance Access originally published online on October 11, 2007
Nucleic Acids Research 2008 36(Database issue):D1048-D1054; doi:10.1093/nar/gkm838
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Nucleic Acids Research, 2008, Vol. 36, Database issue D1048-D1054
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

MUGEN mouse database; Animal models of human immunological diseases

V. Aidinis*, C. Chandras, M. Manoloukos, A. Thanassopoulou, K. Kranidioti, M. Armaka, E. Douni, D. L. Kontoyiannis, M. Zouberakis, G. Kollias{dagger} and the Mugen NoE consortium{ddagger}

B.S.R.C. Alexander Fleming, 34 Fleming Street, 16672, Vari, Greece

* To whom correspondence should be addressed. Tel: +30 210 9654382; Fax: +30 210 9656563; Email: v.aidinis{at}fleming.gr

{dagger}Correspondence may also be addressed to George Kollias. g.kollias{at}fleming.gr

Received August 10, 2007. Revised September 24, 2007. Accepted September 25, 2007.

The MUGEN mouse database (MMdb) (www.mugen-noe.org/database/) is a database of murine models of immune processes and immunological diseases. Its aim is to share and publicize information on mouse strain characteristics and availability from participating institutions. MMdb's basic classification of models is based on three major research application categories: Models of Human Disease, Models of Immune Processes and Transgenic Tools. Data on mutant strains includes detailed information on affected gene(s), mutant allele(s) and genetic background (DNA origin, gene targeted, host and backcross strain background). Each gene/transgene index also includes IDs and direct links to Ensembl, ArrayExpress, EURExpress and NCBI's Entrez Gene database. Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms. Availability (e.g. live mice, cryopreserved embryos, sperm and ES cells) is clearly indicated, along with handling and genotyping details (in the form of documents or hyperlinks) and all relevant contact information (including EMMA and Jax/IMSR hyperlinks where available). MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes. Database access is free of charge and there are no registration requirements for data querying.

{ddagger}The Mugen NoE consortium and contributing members: Aidinis V, Bachmann M, Berns A, Brazma A, de la Torre YM, Di Santo J, Douni E, Fugger L, Garlanda C, Graf D, Granuci F, Haemmerling G, Holmdahl R, Kioussis D, Kollias G, Kontoyiannis DL, Lanzavecchia A, Lowenadler B, Malissen B, Mantovani A, Muller W, Pasparakis M, Persidis A, Pfeffer K, Radbruch A, Rajewsky K, Ricciardi-Castagnoli P, Romagne F, Schneider P, Tocchini – Valentini G, Tschopp J, Van den Broek M, Zacharia L, Zeuthen J


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