Nucleic Acids Research Advance Access originally published online on September 18, 2007
Nucleic Acids Research 2008 36(Database issue):D173-D177; doi:10.1093/nar/gkm696
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Nucleic Acids Research, 2008, Vol. 36, Database issue D173-D177
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
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piRNABank: a web resource on classified and clustered Piwi-interacting RNAs
Institute of Bioinformatics and Applied Biotechnology, Bangalore, India
*To whom correspondence should be addressed. Tel: +91 80 2841 0029, 2841 2769; Fax: +91 80 2841 2761; Email: shipra{at}ibab.ac.in
Received June 21, 2007. Revised July 21, 2007. Accepted August 22, 2007.
Piwi-interacting RNAs (piRNAs) are expressed in mammalian germline cells and have been identified as key players in germline development. These molecules, typically of length 25–33 nt, associate with Piwi proteins of the Argonaute family to form the Piwi-interacting RNA complex. These small regulatory RNAs have been implicated in spermatogenesis, repression of retrotransposon transposition in germline cells, epigenetic regulation and positive regulation of translation and mRNA stability. piRNABank is a highly user-friendly resource which stores empirically known sequences and other related information on piRNAs reported in human, mouse and rat. The database supports organism and chromosome-wise comprehensive search features including accession numbers, localization on chromosomes, gene name or symbol, sequence homology-based search, clusters and corresponding genes and repeat elements. It also displays each piRNA or piRNA cluster on a graphical genome-wide map (http://pirnabank.ibab.ac.in/).
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