Skip Navigation


Nucleic Acids Research Advance Access originally published online on October 2, 2007
Nucleic Acids Research 2008 36(Database issue):D326-D331; doi:10.1093/nar/gkm792
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (2943K) Freely available
Right arrow Screen PDF (581K) Freely available
Right arrowOA All Versions of this Article:
36/suppl_1/D326    most recent
gkm792v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Caboche, S.
Right arrow Articles by Kucherov, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Caboche, S.
Right arrow Articles by Kucherov, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2008, Vol. 36, Database issue D326-D331
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

NORINE: a database of nonribosomal peptides

Ségolène Caboche1,2,*, Maude Pupin1, Valérie Leclère2, Arnaud Fontaine1, Philippe Jacques2 and Gregory Kucherov1

1Computer Science Laboratory of Lille (UMR USTL/CNRS 8022) and INRIA, and 2ProBioGEM (UPRES EA 1026), University of Sciences and Technologies of Lille, 59655 Villeneuve d'A;scq, France

*To whom correspondence should be addressed. Tel: +33 3 59 57 79 17; Fax: +33 3 28 77 85 37; Email: caboche{at}lifl.fr

Received August 14, 2007. Revised September 17, 2007. Accepted September 17, 2007.

Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs). The molecules synthesized by NRPS contain a high proportion of nonproteogenic amino acids. The primary structure of these peptides is not always linear but often more complex and may contain cycles and branchings. In recent years, NRPs attracted a lot of attention because of their biological activities and pharmacological properties (antibiotic, immunosuppressor, antitumor, etc.). However, few computational resources and tools dedicated to those peptides have been available so far. Norine is focused on NRPs and contains more than 700 entries. The database is freely accessible at http://bioinfo.lifl.fr/norine/. It provides a complete computational tool for systematic study of NRPs in numerous species, and as such, should permit to obtain a better knowledge of these metabolic products and underlying biological mechanisms, and ultimately to contribute to the redesigning of natural products in order to obtain new bioactive compounds for drug discovery.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ScienceHome page
A. Tanovic, S. A. Samel, L.-O. Essen, and M. A. Marahiel
Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase
Science, August 1, 2008; 321(5889): 659 - 663.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.