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Nucleic Acids Research Advance Access originally published online on November 4, 2007
Nucleic Acids Research 2008 36(Database issue):D539-D542; doi:10.1093/nar/gkm951
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Nucleic Acids Research, 2008, Vol. 36, Database issue D539-D542
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

VFDB 2008 release: an enhanced web-based resource for comparative pathogenomics

Jian Yang1, Lihong Chen1,2, Lilian Sun1, Jun Yu3 and Qi Jin1,2,*

1State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100176, 2Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100730, China and 3Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Royal College, Glasgow, G1 1XW, UK

*To whom correspondence should be addressed. Tel: +86 10 6787 7732; Fax: +86 10 6787 7736; Email: zdsys{at}sina.com

Received September 12, 2007. Revised October 11, 2007. Accepted October 15, 2007.

Virulence factor database (VFDB) was set up in 2004 dedicated for providing current knowledge of virulence factors (VFs) from various medical significant bacterial pathogens to facilitate pathogenomic research. Nowadays, complete genome sequences of almost all the major pathogenic microbes have been determined, which makes comparative genomics a powerful approach for uncovering novel virulence determinants and hidden aspects of pathogenesis. VFDB was therefore upgraded to present the enormous diversity of bacterial genomes in terms of virulence genes and their organization. The VFDB 2008 release includes the following new features; (i) detailed tabular comparison of virulence composition of a given genome with other genomes of the same genus, (ii) multiple alignments and statistical analysis of homologous VFs and (iii) graphical comparison of genomic organizations of virulence genes. Comparative analysis of the numerous VFs will improve our understanding of the nature and evolution of virulence, as well as the development of new therapeutic and preventive strategies. VFDB 2008 release offers more user-friendly tools for comparative pathogenomics and it is publicly accessible at http://www.mgc.ac.cn/VFs/.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.


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