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Nucleic Acids Research Advance Access originally published online on April 25, 2008
Nucleic Acids Research 2008 36(Web Server issue):W336-W340; doi:10.1093/nar/gkn214
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Nucleic Acids Research, 2008, Vol. 36, No. suppl_2 W336-W340
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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GenoWatch: a disease gene mining browser for association study

Yan-Hau Chen1, Chuan-Kun Liu1, Shu-Chuan Chang1, Yi-Jung Lin1, Ming-Fang Tsai1, Yuan-Tsong Chen1,2 and Adam Yao1,2,*

1National Genotyping Center (NGC) and 2Institute of Biomedical Sciences (IBMS), Academia Sinica, Taipei, Taiwan 11529, R.O.C.

*To whom correspondence should be addressed. Tel: +886 2 26523091; Fax: +886 27824066; Email: adam{at}ibms.sinica.edu.tw

Received January 28, 2008. Revised March 29, 2008. Accepted April 9, 2008.

A human gene association study often involves several genomic markers such as single nucleotide polymorphisms (SNPs) or short tandem repeat polymorphisms, and many statistically significant markers may be identified during the study. GenoWatch can efficiently extract up-to-date information about multiple markers and their associated genes in batch mode from many relevant biological databases in real-time. The comprehensive gene information retrieved includes gene ontology, function, pathway, disease, related articles in PubMed and so on. Subsequent SNP functional impact analysis and primer design of a target gene for re-sequencing can also be done in a few clicks. The presentation of results has been carefully designed to be as intuitive as possible to all users.

The GenoWatch is available at the website http://genepipe.ngc.sinica.edu.tw/genowatch


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