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Nucleic Acids Research 2009 37(3):659-660; doi:10.1093/nar/gkp072
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Nucleic Acids Research, 2009, Vol. 37, No. 3 659-660
© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Editorial: Topoisomerase Special Issue

Topo2008: DNA Topoisomerases in Biology and Medicine

Tony Maxwell

John Innes Centre, Norwich, UK

Andy Bates

University of Liverpool, Liverpool, UK

The first 10% of the full text of this article appears below.

The DNA topoisomerases are a group of fascinating enzymes that play an essential but dangerous game with DNA. They break and rejoin either one or both strands of the double helix to solve the problems of tangling and linking that occur as a result of DNA manipulations (replication, transcription and recombination) in all cells. This basic problem with the DNA structure was recognized by Watson and Crick almost as soon as the double helix was described (1). As the parental DNA strands are separated at a replication fork, the double-helical turns are compressed and overwound . . . [Full Text of this Article]


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