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Nucleic Acids Research Advance Access originally published online on November 7, 2008
Nucleic Acids Research 2009 37(Database issue):D105-D110; doi:10.1093/nar/gkn851
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Nucleic Acids Research, 2009, Vol. 37, Database issue D105-D110
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

miRecords: an integrated resource for microRNA–target interactions

Feifei Xiao1, Zhixiang Zuo1, Guoshuai Cai1, Shuli Kang1, Xiaolian Gao2 and Tongbin Li1,*

1Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, 2Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA

*To whom correspondence should be addressed. Tel: +1 612 626 3481; Fax: +1 612 626 5009; Email: toli{at}biocompute.umn.edu

Received August 15, 2008. Revised September 21, 2008. Accepted October 16, 2008.

MicroRNAs (miRNAs) are an important class of small noncoding RNAs capable of regulating other genes’ expression. Much progress has been made in computational target prediction of miRNAs in recent years. More than 10 miRNA target prediction programs have been established, yet, the prediction of animal miRNA targets remains a challenging task. We have developed miRecords, an integrated resource for animal miRNA–target interactions. The Validated Targets component of this resource hosts a large, high-quality manually curated database of experimentally validated miRNA–target interactions with systematic documentation of experimental support for each interaction. The current release of this database includes 1135 records of validated miRNA–target interactions between 301 miRNAs and 902 target genes in seven animal species. The Predicted Targets component of miRecords stores predicted miRNA targets produced by 11 established miRNA target prediction programs. miRecords is expected to serve as a useful resource not only for experimental miRNA researchers, but also for informatics scientists developing the next-generation miRNA target prediction programs. The miRecords is available at http://miRecords.umn.edu/miRecords.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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