Nucleic Acids Research Advance Access originally published online on October 29, 2008
Nucleic Acids Research 2009 37(Database issue):D175-D180; doi:10.1093/nar/gkn815
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Nucleic Acids Research, 2009, Vol. 37, Database issue D175-D180
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
Articles |
CentrosomeDB: a human centrosomal proteins database
1Computer Architecture Department, Complutense University of Madrid and 2National Center for Biotechnology, CNB-CSIC, Madrid, Spain
*To whom correspondence should be addressed. Tel: +34 913944420; Fax: +34 913944687; Email: pascual{at}fis.ucm.es
Received August 9, 2008. Revised September 30, 2008. Accepted October 12, 2008.
Active research on the biology of the centrosome during the past decades has allowed the identification and characterization of many centrosomal proteins. Unfortunately, the accumulated data is still dispersed among heterogeneous sources of information. Here we present centrosome:db, which intends to compile and integrate relevant information related to the human centrosome. We have compiled a set of 383 likely human centrosomal genes and recorded the associated supporting evidences. Centrosome:db offers several perspectives to study the human centrosome including evolution, function and structure. The database contains information on the orthology relationships with other species, including fungi, nematodes, arthropods, urochordates and vertebrates. Predictions of the domain organization of centrosome:db proteins are graphically represented at different sections of the database, including sets of alternative protein isoforms, interacting proteins, groups of orthologs and the homologs identified with blast. Centrosome:db also contains information related to function, gene–disease associations, SNPs and the 3D structure of proteins. Apart from important differences in the coverage of the set of centrosomal genes, our database differentiates from other similar initiatives in the way information is treated and analyzed. Centrosome:db is publicly available at http://centrosome.dacya.ucm.es.
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.
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