Nucleic Acids Research Advance Access originally published online on October 21, 2008
Nucleic Acids Research 2009 37(Database issue):D412-D416; doi:10.1093/nar/gkn760
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Nucleic Acids Research, 2009, Vol. 37, Database issue D412-D416
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
Articles |
STRING 8—a global view on proteins and their functional interactions in 630 organisms
1European Molecular Biology Laboratory, Heidelberg, Germany, 2Novo Nordisk Foundation Centre for Protein Research, University of Copenhagen, Denmark, 3Institute of Molecular Biology and Swiss Institute of Bioinformatics, University of Zurich, 4Centre for Integrative Genomics, University of Lausanne, Switzerland and 5Max-Delbrück-Centre for Molecular Medicine, Berlin, Germany
*To whom correspondence should be addressed. Tel: +49 6221 3878526; Fax: +49 6221 387519; Email: bork{at}embl.de
Correspondence may also be addressed to Christian von Mering. Tel: +41 44 6353147; Fax: +41 44 6356864; Email: mering{at}molbio.uzh.ch
Received September 14, 2008. Accepted October 6, 2008.
Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation. STRING is a database and web resource dedicated to protein–protein interactions, including both physical and functional interactions. It weights and integrates information from numerous sources, including experimental repositories, computational prediction methods and public text collections, thus acting as a meta-database that maps all interaction evidence onto a common set of genomes and proteins. The most important new developments in STRING 8 over previous releases include a URL-based programming interface, which can be used to query STRING from other resources, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures. Version 8.0 of STRING covers about 2.5 million proteins from 630 organisms, providing the most comprehensive view on protein–protein interactions currently available. STRING can be reached at http://string-db.org/.
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in Nucl. Acids Res.:
- Subscriptions
Nucl. Acids Res. 2009 37: iii.[Extract] [FREE Full Text]
This article has been cited by other articles:
|
|
 |
|
  B. Kollerits, S. Coassin, N. D. Beckmann, A. Teumer, S. Kiechl, A. Doring, M. Kavousi, S. C. Hunt, C. Lamina, B. Paulweber, et al. Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins Hum. Mol. Genet., December 1, 2009; 18(23): 4669 - 4676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kuhner, V. van Noort, M. J. Betts, A. Leo-Macias, C. Batisse, M. Rode, T. Yamada, T. Maier, S. Bader, P. Beltran-Alvarez, et al. Proteome Organization in a Genome-Reduced Bacterium Science, November 27, 2009; 326(5957): 1235 - 1240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Gould, F. Diella, A. Via, P. Puntervoll, C. Gemund, S. Chabanis-Davidson, S. Michael, A. Sayadi, J. C. Bryne, C. Chica, et al. ELM: the status of the 2010 eukaryotic linear motif resource Nucleic Acids Res., November 17, 2009; (2009) gkp1016v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Uchiyama, T. Higuchi, and M. Kawai MBGD update 2010: toward a comprehensive resource for exploring microbial genome diversity Nucleic Acids Res., November 11, 2009; (2009) gkp948v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Syed, M. D'Antonio, and F. D. Ciccarelli Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes Nucleic Acids Res., November 11, 2009; (2009) gkp957v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Jung and H. Jung A New Mechanism of Phosphoregulation in Signal Transduction Pathways Sci. Signal., November 10, 2009; 2(96): pe71 - pe71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Muller, D. Szklarczyk, P. Julien, I. Letunic, A. Roth, M. Kuhn, S. Powell, C. von Mering, T. Doerks, L. J. Jensen, et al. eggNOG v2.0: extending the evolutionary genealogy of genes with enhanced non-supervised orthologous groups, species and functional annotations Nucleic Acids Res., November 9, 2009; (2009) gkp951v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kuhn, D. Szklarczyk, A. Franceschini, M. Campillos, C. von Mering, L. J. Jensen, A. Beyer, and P. Bork STITCH 2: an interaction network database for small molecules and proteins Nucleic Acids Res., November 6, 2009; (2009) gkp937v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lysenko, M. M. Hindle, J. Taubert, M. Saqi, and C. J. Rawlings Data integration for plant genomics--exemplars from the integration of Arabidopsis thaliana databases Brief Bioinform, November 1, 2009; 10(6): 676 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Vanhee, J. Reumers, F. Stricher, L. Baeten, L. Serrano, J. Schymkowitz, and F. Rousseau PepX: a structural database of non-redundant protein-peptide complexes Nucleic Acids Res., October 30, 2009; (2009) gkp893v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res., October 20, 2009; (2009) gkp846v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kuchta, L. Knizewski, L. S. Wyrwicz, L. Rychlewski, and K. Ginalski Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human Nucleic Acids Res., October 15, 2009; (2009) gkp854v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gu, Y. Wang, and T. Lilburn A Comparative Genomics, Network-Based Approach to Understanding Virulence in Vibrio cholerae J. Bacteriol., October 15, 2009; 191(20): 6262 - 6272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Donohoe, J. Walters, D. W. Morris, E. M. Quinn, R. Judge, N. Norton, I. Giegling, A. M. Hartmann, H.-J. Moller, P. Muglia, et al. Influence of NOS1 on Verbal Intelligence and Working Memory in Both Patients With Schizophrenia and Healthy Control Subjects Arch Gen Psychiatry, October 1, 2009; 66(10): 1045 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yang, L. Xu, and L. He A CitationRank algorithm inheriting Google technology designed to highlight genes responsible for serious adverse drug reaction Bioinformatics, September 1, 2009; 25(17): 2244 - 2250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Choudhary, C. Kumar, F. Gnad, M. L. Nielsen, M. Rehman, T. C. Walther, J. V. Olsen, and M. Mann Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions Science, August 14, 2009; 325(5942): 834 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Blankenburg, F. Ramirez, J. Buch, and M. Albrecht DASMIweb: online integration, analysis and assessment of distributed protein interaction data Nucleic Acids Res., July 1, 2009; 37(suppl_2): W122 - W128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. James, T. L. Biechele, W. H. Conrad, N. D. Camp, D. M. Fass, M. B. Major, K. Sommer, X. Yi, B. S. Roberts, M. A. Cleary, et al. Bruton's Tyrosine Kinase Revealed as a Negative Regulator of Wnt-{beta}-Catenin Signaling Sci. Signal., May 26, 2009; 2(72): ra25 - ra25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Blankenburg, R. D. Finn, A. Prlic, A. M. Jenkinson, F. Ramirez, D. Emig, S.-E. Schelhorn, J. Buch, T. Lengauer, and M. Albrecht DASMI: exchanging, annotating and assessing molecular interaction data Bioinformatics, May 15, 2009; 25(10): 1321 - 1328. [Abstract] [Full Text] [PDF]
|
|