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Nucleic Acids Research Advance Access originally published online on October 30, 2008
Nucleic Acids Research 2009 37(Database issue):D669-D673; doi:10.1093/nar/gkn739
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Nucleic Acids Research, 2009, Vol. 37, Database issue D669-D673
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

VirusMINT: a viral protein interaction database

Andrew Chatr-aryamontri1, Arnaud Ceol1, Daniele Peluso1,2, Aurelio Nardozza1, Simona Panni3, Francesca Sacco1, Michele Tinti1, Alex Smolyar4, Luisa Castagnoli1, Marc Vidal4, Michael E. Cusick4 and Gianni Cesareni1,2,*

1Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, 2IRCCS Fondazione Santa Lucia, 00143 Rome, 3Department of Cell Biology, University of Calabria, Via P. Bucci, Rende (CS) Italy and 4Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA

*To whom correspondence should be addressed. Tel: +39 0672594315; Fax: +39 062023500; Email: cesareni{at}uniroma2.it

Received August 13, 2008. Revised September 20, 2008. Accepted October 2, 2008.

Understanding the consequences on host physiology induced by viral infection requires complete understanding of the perturbations caused by virus proteins on the cellular protein interaction network. The VirusMINT database (http://mint.bio.uniroma2.it/virusmint/) aims at collecting all protein interactions between viral and human proteins reported in the literature. VirusMINT currently stores over 5000 interactions involving more than 490 unique viral proteins from more than 110 different viral strains. The whole data set can be easily queried through the search pages and the results can be displayed with a graphical viewer. The curation effort has focused on manuscripts reporting interactions between human proteins and proteins encoded by some of the most medically relevant viruses: papilloma viruses, human immunodeficiency virus 1, Epstein–Barr virus, hepatitis B virus, hepatitis C virus, herpes viruses and Simian virus 40.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.


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A. Ceol, A. Chatr Aryamontri, L. Licata, D. Peluso, L. Briganti, L. Perfetto, L. Castagnoli, and G. Cesareni
MINT, the molecular interaction database: 2009 update
Nucleic Acids Res., November 6, 2009; (2009) gkp983v1.
[Abstract] [Full Text] [PDF]


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