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Nucleic Acids Research Advance Access originally published online on November 6, 2008
Nucleic Acids Research 2009 37(Database issue):D767-D772; doi:10.1093/nar/gkn892
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Nucleic Acids Research, 2009, Vol. 37, Database issue D767-D772
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

Human Protein Reference Database—2009 update

T. S. Keshava Prasad1, Renu Goel1, Kumaran Kandasamy1,2,3,4,5, Shivakumar Keerthikumar1,2, Sameer Kumar1,2, Suresh Mathivanan1,2, Deepthi Telikicherla1,2, Rajesh Raju1,2, Beema Shafreen1, Abhilash Venugopal1,2, Lavanya Balakrishnan1, Arivusudar Marimuthu1,3,4,5, Sutopa Banerjee1, Devi S. Somanathan1, Aimy Sebastian1, Sandhya Rani1, Somak Ray1, C. J. Harrys Kishore1, Sashi Kanth1, Mukhtar Ahmed1, Manoj K. Kashyap1,2,3,4,5, Riaz Mohmood2, Y. L. Ramachandra2, V. Krishna2, B. Abdul Rahiman2, Sujatha Mohan1, Prathibha Ranganathan1, Subhashri Ramabadran1, Raghothama Chaerkady1,3,4,5 and Akhilesh Pandey3,4,5,*

1Institute of Bioinformatics, International Tech Park, Bangalore 560 066, 2Department of Biotechnology, Kuvempu University, Shankaraghatta, Karnataka, India, 3McKusick-Nathans Institute of Genetic Medicine, 4Department of Biological Chemistry and 5Department of Pathology and Oncology, Johns Hopkins University, Baltimore, MD 21205, USA

*To whom correspondence should be addressed. Tel: +410 502 6662; Fax: +410 502 7544; Email: pandey{at}jhmi.edu

Correspondence may also be addressed to T. S. Keshava Prasad. Tel: (+91) 80-28416140; Fax: (+91) 80-28416132; Email: keshav{at}ibioinformatics.org

Received September 16, 2008. Revised October 20, 2008. Accepted October 22, 2008.

Human Protein Reference Database (HPRD—http://www.hprd.org/), initially described in 2003, is a database of curated proteomic information pertaining to human proteins. We have recently added a number of new features in HPRD. These include PhosphoMotif Finder, which allows users to find the presence of over 320 experimentally verified phosphorylation motifs in proteins of interest. Another new feature is a protein distributed annotation system—Human Proteinpedia (http://www.humanproteinpedia.org/)—through which laboratories can submit their data, which is mapped onto protein entries in HPRD. Over 75 laboratories involved in proteomics research have already participated in this effort by submitting data for over 15 000 human proteins. The submitted data includes mass spectrometry and protein microarray-derived data, among other data types. Finally, HPRD is also linked to a compendium of human signaling pathways developed by our group, NetPath (http://www.netpath.org/), which currently contains annotations for several cancer and immune signaling pathways. Since the last update, more than 5500 new protein sequences have been added, making HPRD a comprehensive resource for studying the human proteome.


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