Nucleic Acids Research Advance Access originally published online on October 8, 2008
Nucleic Acids Research 2009 37(Database issue):D863-D867; doi:10.1093/nar/gkn682
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Nucleic Acids Research, 2009, Vol. 37, Database issue D863-D867
© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]
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RAPID: Resource of Asian Primary Immunodeficiency Diseases
1Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India, 2Research Unit for Immunoinformatics, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan, 3Department of Life Science, Kuvempu University, Jnanasahyadri, Shimoga 577 451, India, 4McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA, 5Laboratory for Immunogenomics, Research Center for Allergy and Immunology, RIKEN, Yokohama Institute, Kanagawa 230-0045, Japan, 6Department of Computer Science and Automation, Indian Institute of Science, Bangalore-12, India, 7Department of Pediatrics, National Defense Medical College, Saitama 359-8513, Japan, 8Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194 and 9Department of Human Genome Technology, Kazusa DNA Research Institute, Chiba 292-0818, Japan
*To whom correspondence should be addressed. Tel: +81 45 503 9695; Fax: +81 45 503 9694; Email: oosamu{at}rcai.riken.jp
Correspondence may also be addressed to Sujatha Mohan. Tel: +81 45 503 7034; Fax: +81 45 503 9694; Email: sujatha{at}rcai.riken.jp
Received August 15, 2008. Revised September 21, 2008. Accepted September 23, 2008.
Availability of a freely accessible, dynamic and integrated database for primary immunodeficiency diseases (PID) is important both for researchers as well as clinicians. To build a PID informational platform and also as a part of action to initiate a network of PID research in Asia, we have constructed a web-based compendium of molecular alterations in PID, named Resource of Asian Primary Immunodeficiency Diseases (RAPID), which is available as a worldwide web resource at http://rapid.rcai.riken.jp/. It hosts information on sequence variations and expression at the mRNA and protein levels of all genes reported to be involved in PID patients. The main objective of this database is to provide detailed information pertaining to genes and proteins involved in primary immunodeficiency diseases along with other relevant information about protein–protein interactions, mouse studies and microarray gene-expression profiles in various organs and cells of the immune system. RAPID also hosts a tool, mutation viewer, to predict deleterious and novel mutations and also to obtain mutation-based 3D structures for PID genes. Thus, information contained in this database should help physicians and other biomedical investigators to further investigate the role of these molecules in PID.
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