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Nucleic Acids Research Advance Access originally published online on May 8, 2009
Nucleic Acids Research 2009 37(Web Server issue):W40-W47; doi:10.1093/nar/gkp361
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Nucleic Acids Research, 2009, Vol. 37, No. suppl_2 W40-W47
© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles

Writing DNA with GenoCADTM

Michael J. Czar, Yizhi Cai and Jean Peccoud*

Virginia Bioinformatics Institute at Virginia Polytechnic and State University, Blacksburg, VA 24061, USA

*To whom correspondence should be addressed. Tel: +540 231 0403; Fax: +540 231 2606; Email: peccoud{at}vt.edu

Received March 13, 2009. Revised April 21, 2009. Accepted April 22, 2009.

Chemical synthesis of custom DNA made to order calls for software streamlining the design of synthetic DNA sequences. GenoCADTM (www.genocad.org) is a free web-based application to design protein expression vectors, artificial gene networks and other genetic constructs composed of multiple functional blocks called genetic parts. By capturing design strategies in grammatical models of DNA sequences, GenoCAD guides the user through the design process. By successively clicking on icons representing structural features or actual genetic parts, complex constructs composed of dozens of functional blocks can be designed in a matter of minutes. GenoCAD automatically derives the construct sequence from its comprehensive libraries of genetic parts. Upon completion of the design process, users can download the sequence for synthesis or further analysis. Users who elect to create a personal account on the system can customize their workspace by creating their own parts libraries, adding new parts to the libraries, or reusing designs to quickly generate sets of related constructs.


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[Abstract] [Full Text] [PDF]


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