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Nucleic Acids Research, 1977, Vol. 4, No. 10 3557-3562
© 1977

Articles

Genes for {Upsilon}-globin in human adult erythroid DNA

G. Joan Mitchell and R. Williamson*

Beatson Institute for Cancer Research Glasgow, G61 *Department of Biochemistry, St. Mary's Hospital Medical School, University of London W2 IPG, UK

Received July 21, 1977. Purified {gamma}-globin specific complementary DNA has been used to demonstrate the presence of the gene for {gamma}-globin in DNA from human adult red blood cells. This finding sheds doubt on any theory involving looping-out excision of genes to explain the switch over from synthesis of {gamma}-globin to ß-globin at birth.


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