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Nucleic Acids Research, 1977, Vol. 4, No. 12 4249-4260
© 1977

Articles

Polynucleotides. L. Synthesis and properties of poly (2' - chloro - 2' - deoxyadenylic acid) and poly (2' - bromo - 2' - deoxyadenylic acid)

Morio Ikehara, Toshikazu Fukui and Nobuko Kakiuchi

Faculty of Pharmaceutical Sciences, Osaka University Suita, Osaka, Japan 565

Received September 9, 1977. Poly (2'-chloro-2'-deoxyadenylic acid) and poly (2'-bromo- 2'-deoxyadenylic acid) were synthesized from the corresponding diphosphates with the aid of polynucleotide phosphorylase from E. coli. UV, CD, acid titration and mixing with poly (U) were investigated. Comparing these properties with those of poly (A) and poly (2'-azido-2'-deoxyadenylic acid), it was found that 2'-substituents exert significant effects on the thermal stability of these polynucleotides, though the overall conformational structure was not greatly changed.


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