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Nucleic Acids Research, 1977, Vol. 4, No. 5 1381-1392
© 1977

Articles

An ethidium-induced double helix of poly(dA)-poly(rU)*

Edward A. Lehrman and Donald M. Crothers

Department of Chemistry, Yale University New Haven, CT 06520, USA

Received February 1, 1977.

Equilibrium dialysis, relaxation kinetic, melting, and continuous variation mixing experiments on complexes of poly(dA) and poly(rU) demonstrate that ethidium induces conversion of a 1:1 mixture of these homopolymers (at one molar salt and 19°C) from a three stranded to a two stranded helix. This is the first demonstration of a double helix of poly(dA).poly(rU) in solution.

*Dedicated to Jerome Vinograd.


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