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Nucleic Acids Research, 1977, Vol. 4, No. 6 1769-1782
© 1977

Articles

Methylation of an adenosine in the D-loop of specific transfer RNAs from yeast by a procaryotic tRNA (adenine-1) methyltransferase

R. Raettig, H. Kersten, J. Weissenbach+ and G. Dirheimer+

Inst. Physiol. Chem. Wasserturmstrasse 5, 8520 Erlangen, GFR +Inst. Biol. Mol. et Cell du C.N.R.S., 15, rue Descartes, and Fac. Pharm., Univ. Louis Pasteur, Strasbourg, France.

Received January 26, 1977. tRNA (adenine-1) methyltransferase occurs in Bacillus subtilis. Eucaryotic tRNAThr anci tRNAThr from yeast in which 1-methyladenosine (m1A) is already present in the T{psi}C loop, can be methylated in vitro with S-adenosylmethionine and B. subtilis extracts. Each of the specific tRNAs accepts 1 mol of methyl groups per mol tRNA. The enzyme transforms into m1A the 3'-terminal adenylic acid residue of the di-hydrouridine loop, a new position for a modified adenosine residue in tRNA. Both tRNAs have the sequence Formula in the D-loop and D-stetn region. Other tRNAs with the same sequence in this region also serve as substrates for the tRNA (adenine-1) methyltransferase.


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