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Nucleic Acids Research, 1977, Vol. 4, No. 6 1945-1956
© 1977

Articles

Biosynthesis of tRNA in histidine regulatory mutants of Salmonella typhimurium

Lionello Bossi and Riccardo Cortese{dagger}

I and II Istituto di Chimica Biologica, II Facoltaà di Medicina e Chirurgia, Universitaà di Napoli Napoli, Italy

Received March 16, 1977.

HisU mutants of Salmonella typhimurium are depressed in the histidine operon since they have lower intracellular concentration of histidyl-tRNAHis. in this paper we present evidences showing that a strain carrying a hisU mutation (hisUl206) is altered in a nucleolytic enzyme involved in tRNA maturation process. The analysis of several hisU mutants indicates that hisU region of bacterial genome may account for more than one function involved in tRNA biosynthesis.

{dagger}Present address: M.R.C. Laboratory of Molecular Biology, Postgraduate Medical School, University of Cambridge, Hills Road, Cambridge, Great Britain CB2 2Q14.


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A.-B. Blanc-Potard, N. Figueroa-Bossi, and L. Bossi
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