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Nucleic Acids Research, 1977, Vol. 4, No. 8 2629-2640
© 1977

Articles

Polynucleotides. XLV1) Synthesis and properties of poly(2'-azido-2'-deoxyinosinic acid)

Toshikazu Fukui, Nubuko Kakiuchi and Morio Ikehara

Faculty of Pharmaceutical Sciences, Osaka University Suita, Osaka, Japan 565

Received April 14, 1977. Poly (2'-azido-2'-deoxyinosinic acid), [poly (Iz)] , was synthesized from 2'-azido-2'-deoxyinosine diphosphate by the action of polynucleotide phosphorylase. Poly (Iz) has UV absorption properties similar to poly (I) and hypochromicity of 11% at 0.15M Na+ and neutrality. In solutions of high Na+ ion concentration, poly (Iz) forms a multi-stranded complex and its Tm at 1.0M Na+ ion concentration was 43°. Upon mixing with poly (C), poly (Iz) forms a 1:1 complex having a Tm lower than that of poly (I)·poly (C) complex in the same conditions. The effect of substitution at the 2'-position of the poly (I) strand was discussed in relation to the interferon-inducing activity.


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