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Nucleic Acids Research, 1978, Vol. 5, No. 10 3731-3742
© 1978

Articles

Photosensitization of DNA by gold

R.J. Wilkins

Department of Biochemistry, Univetsity of Otago Medical School Dunedin, New Zealand

Received August 9, 1978. Au(III) reacts with DNA at pH 5.6 to form a complex which is sensitive to mid-UV radiation. Cyclobutane pyrimidine dimers are produced at some 15 to 30 times the rate that they are in untreated DNA. The mechanism of photosensitization appears to involve energy absorption by Au-purine and Au-cytosine adducts which can then transfer energy to thymine residues. There is no evidence for a "heavy atom" effect which enables metals such as Ag to mix excited states of DNA and to increase the quantum yields of some photoproducts. The use of mid-UV radiation as a probe for investigating the interaction between DNA and drugs such as sodium aurothiomalate is discussed.


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