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Nucleic Acids Research, 1978, Vol. 5, No. 3 951-960
© 1978

Articles

Xeroderma pigmentosum fibroblasts of the D group lack an apurinic DNA endonuclease species with a low apparent Km

Urs Kuhnlein*, Betty Lee**, Edward E. Penhoet and Stuart Linn

Department of Biochemistry, University of California Berkeley, CA 94720, USA

Received January 18, 1978.

Apurinic DNA endonuclease activity from cultured human fibroblasts was resolved into two species by phosphocellulose chromatography. The species had sedimentation coefficients of 3.3 S and 2.8 S and apparent Km' S for apurinic sites of 5 and 44 nM, respectively. The low Km species was absent from extracts of cell lines XP5BE, XP6BE and XP7BE of xeroderma pigmentosum complementation group D.

*Current address: Biophysics Dept., B.C. Cancer Foundation, Vancouver, B.C., Canada V5Z 3K3

**Current address: Harvard Medical School, Boston, Mass. 02115


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