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Nucleic Acids Research, 1978, Vol. 5, No. 4 1315-1324
© 1978

Articles

Hydrogen bonding interactions of polyamines with the 2' OH of RNA

Philip H. Bolton and David R. Kearns

Department of Chemistry, University of California San Diego, La Jolla, CA 92093, USA

Received January 26, 1978. Polyamines and other charged amines bind to RNA by hydrogen bonding to the 3' phosphate and to the 2' OH. This mode of binding suggests a mechanism by which DNA and RNA might be distinguished by enzymes.


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