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Nucleic Acids Research, 1978, Vol. 5, No. 6 1955-1970
© 1978

Articles

Base pairing structure in the poly d(G-T) double helix: wobble base pairs

Thomas A. Early, John Olmsted, III, David R. Kearns and Axel G. Lezius{dagger}

Department of Chemistry, Revelle College, University of California San Diego, La Jolla, CA 92093, USA {dagger}Max-Planck-Institut für Experimentelle Medizin Abt. Chemie, Göttingen, GFR

Received March 27, 1978. High resolution nuclear magnetic resonance (NMR) and ethidium bromide binding studies are used to demonstrate that poly d(G-T) forms an ordered double helical structure at low temperatures (below 24°C in 0.3 M NaCl) in which G and T are hydrogen bonded together in a wobble base pair hydrogen bonding scheme as proposed earlier by Lezius and Domin1. Alternative hydrogen bonding schemes involving the tautomeric form of either T or G, such as have been proposed to account for mutation rates in DNA synthesis, are eliminated.


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