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Nucleic Acids Research, 1978, Vol. 5, No. 6 2189-2196
© 1978

Articles

DNA polymerases {alpha} ß and {gamma} inherited diseases affecting DNA repair

Umbetazzoni Bertazzoni, Anna I. Scovassi, Miria Stefanini, Elena Giulotto, Silvio Spadari and Antonia M. Pedrini

Laboratorio di Genetica Biochimica ed Evoluzionistica del Consigilo Nazionale delle Ricerche 27100 Pavia, and Istituto di Genetica dell'Università Via S. Epifanio, 14,27100 Pavia, Italy

Received February 7, 1978. Fibroblasts derived from patients with diseases affecting DNA repair processes, such as Xeroderma Pigmentosum (classical and vari ant), Fanconi's anemia, Bloom's syndrome, Ataxia Telangiectasica, Progeria and Werner's syndrome, were assayed for the three DNA polymerases. The specific activities of these enzymes were found within the limits observed in normal human fibroblasts. Also the sedimentation properties of the three polymerases were unaltered.


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