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Nucleic Acids Research, 1978, Vol. 5, No. 9 3141-3156
© 1978

Articles

Nucleotide sequence of the O gene and of the origin of replication in bacteriophage lambda DNA

Gerd Scherer+

Institut fur Biologie III der Universitat Freiburg D-7800 Freiburg i. Br., GFR

Received July 11, 1978.

The nucleotide sequence of the O gene in bacteriophage lambda DNA is presented. According to two possible initiator codons, the primary structure of the O protein deduced from the DNA sequence consists of 278 or 299 amino acid residues. Structure and function of the O protein - one of the two phage initiator proteins for lambda DNA replication - are discussed in the light of a secondary structure model for the O protein.

The central part of the O gene contains a cluster of symmetrical sequences extending over 160 base pairs. The point mutation of the cis-dominant replication mutant ti12 is located in this region.

+ Present address : European Molecular Biology Laboratory, Postfach 10.2209, D-6900 HEIDELBERG, FRG.


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