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Nucleic Acids Research, 1980, Vol. 8, No. 12 2591-2604
© 1980

Articles

Structure of the host-derived sequences present at the 5' ends of influenza virus mRNA

Andrew J. Caton and S. Robertson

Division of Virology, Department of Pathology, University of Cambridge Addenbrooke's Hospital, Hills Road, Cambridge, UK

Received May 16, 1980. Nucleotide sequence analysis of the terminal virus-coded regions of a clone of the matrix gene of influenza virus indicated that the region corresponding to the 5' end of the mRNA contains an additional 13 non-virus coded nucleotides. Using the dideoxy-chain termination sequencing method with a restriction fragment derived from this clone, we have determined that the 5' ends of matrix gene mRNAs contain a heterogenous sequence of 9–15 nucleotides. In addition, the data indicate that the 3' terminal nucleotide of matrix gene virion RNA is not transcribed into mRNA, transcription of influenza virus-specific sequences commencing with the penultimate nucleotide at the 3' end of virion RNA.


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