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Nucleic Acids Research, 1980, Vol. 8, No. 15 3319-3333
© 1980

MOLECULAR BIOLOGY

Repetitive DNA sequences near three human ß-type globin genes

Lesley W. Coggins, G.Joan Grindlay, J.Keith Vass, Alison A. Slater, Paul Montague, M.Anne Stinson and John Paul

The Beatson Institute for Cancer Research, Wolfson Laboratory for Molecular Pathology, Garscube Estate Switchback Road, Bearsden, Glasgow, G61 1BD, UK

Received June 10, 1980. Pive repetitive DNA sequences, of average length 259 bp, have been identified in the intergenic regions which flank three human ß-type globin genes. A pair of inverted repeat sequences, separated by 919 bp, waa found 1.0 kb to the 5' side of the epsilon-globin gene. Each contains a homologous Alu I site. Another repetitive sequence, with the same orientation as the inverted repeat sequence closest to the epsilon-globin gene, lies about 2.2 kb to the 5' side of the delta-globin gene. A pair of inverted repeat sequences, with the same relative orientations as the other pair and separated by about 800 bp, was found about 1.5 kb to the 3' side of the ß-globin gene.


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C. Schmid and W. Jelinek
The Alu family of dispersed repetitive sequences
Science, June 4, 1982; 216(4550): 1065 - 1070.
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