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Nucleic Acids Research, 1980, Vol. 8, No. 23 5825-5833
© 1980

MOLECULAR BIOLOGY

Deletions and DNA rearrangements within the transposable DNA element IS2. A model for the creation of palindromic DNA by DNA repair synthesis

Jürgen Besemer*, Gabriele Görtz and Daniel Charlier

Institut für Genetik der Universität Köln D-5000 Köln 41, Weyertal 121, GFR

*Correspondence should be addressed to Jürgen Besemer, Sandoz Forschungs institut, Brunner Strasse 59, A-1235 Wien, Austria

Received September 25, 1980. Three derivatives of mutant galOP-308::IS2-I of Escherichia coli were characterized by DNA sequence analysis. Deletions and DNA sequence rearrangements were observed which apparently were initiated at short A-T rich inverted repeats within IS2. Two of the mutants carried newly synthesized DNA sequences which were inverted copies of already existing IS2 sequences. Thus long stretches with twofold symmetry were formed. It is discussed whether these inverted repeats were formed by DNA repair synthesis which was initiated at the A-T rich palindromes of IS2.


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