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Nucleic Acids Research, 1980, Vol. 8, No. 24 6113-6128
© 1980

MOLECULAR BIOLOGY

A family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene

J.W. Adams*, R.E. Kaufman*, P.J. Kretschmer+, M. Harrison+ and A.W. Nienhuis

*Clinical Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health Bethesda, MD 20205, USA +Laboratory of Molecular Hematology, National Heart, Lung and Blood Institute, National Institutes of Health Bethesda, MD 20205, USA

Received September 23, 1980. An unusually long repeated DNA sequence was identified in cloned DNA, three kb 3' to the human ß-globin gene. Other members of this repeated sequence family were isolated from a human genomic DNA library and characterized by Southern blotting techniques, electron microscopy, and solution hybridization. The copy located next to the ß-globin gene was found to be 6.4 +/– 0.2 kb long and continuous over that length. This repeated sequence family comprises about 1% of the human genome and contains 3000–4800 copies of moderate sequence divergence which are interspersed with other less-highly repeated DNA. The 6.4 kb repeated unit does not appear to be composed of any smaller tandemly repeated subunits, nor is it expressed at a high level in bone marrow cell RNA.


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