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Nucleic Acids Research, 1980, Vol. 8, No. 6 1217-1230
© 1980

Articles

The structure of poliovirus replicative form

Glenn R. Larsen, Andrew J. Domer, Timothy J.R. Harris* and Eckard Wimmer

Department of Microbiology, State University of New York at Stony Brook Stony Brook, NY 11794, USA

Received February 13, 1980.

The structure of polio replicative form (RF) has been investigated by 3' end labeling and the use of polynucleotide phosphorylase to now allow a complete composite of the RF structure. The evidence presented indicates that the 3' terminal sequence of the minus strand is an exact complement to the 5' end of polio RNA. This suggests that the 5' terminal U of polio RNA is genetically coded. Other data is presented to show that in addition to the genetically coded poly(A) tract of the plus strand in RF, a single-stranded poly(A) tail protrudes beyond the double-stranded RNA.

*On leave from the Animal Virus Research Institute, Pirbright, Woking, Surrey, United Kingdom


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