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Nucleic Acids Research, 1980, Vol. 8, No. 7 1643-1660
© 1980

Articles

Frequency distribution of pre-messenger RNA sequences in polyadenylated and non-polyadenylated nuclear RNA from Friend cells

A. Balmain, A.J. Minty and G.D. Birnie

Beatson Institute for Cancer Research, Wolfson Laboratory for Molecular Pathology Garscube Estate, Switchback Road, Bearsden, Glasgow, G61, UK

Received January 31, 1980. Hybridisation of cDNA probes for abundant and rare polysomal polyadenylated RNAs with polyadenylated and non-polyadenylated nuclear RNA from Friend cells indicated that the abundant polysomal polyadenylated RNA sequences were present at a higher concentration in the nuoleus than rare polysomal sequences, but at a reduced range of concentrations. The ratio of the concentrations of abundant and rare sequences was about 3 in non-polyadenylated nuclear RNA, 9 in polyadenylated nuolear RNA and 13 in polysonal polysdenylated RNA. This suggests that polyadenylation may-play a role in the quantitative selection of sequences for transport to the cytoplasm. Polyadenylation cannot be the only signal for transport, since a highly complex population of nucleus-onfined polyadenylated molecules exists, each of which is present on average at less than one copy per cell.


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