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Nucleic Acids Research, 1980, Vol. 8, No. 9 2105-2115
© 1980

Articles

The chemical synthesis of oligoribonucleotides VII. A comparison of condensing agents in the coupling of silybted ribonucleosides

Kelvin K. Ogilvie and Richard T. Pon

Department of Chemistry, McGill University Montreal, Quebec, H3A 2K6, Canada

Received January 15, 1980. The t-butyldimethylsilyl group is shown to be an ideal protecting gruoup for the 2T-hydroxyl function of ribonucleosides during the synthesis of ribonucleotides using any of nine commonly used condensing agents. The phosphite coupling procedure compares, favorably with all of the widely used condensing agents and provides a most convenient route to the key intermediates in the modified triester strategy.


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