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Nucleic Acids Research, 1981, Vol. 9, No. 1 1-17
© 1981

MOLECULAR BIOLOGY

The sequence of the 3' non-coding region of the hexon mRNA discloses a novel adenovirus gene

Göran Akusjärvi*, Jan Zabielski, Michel Perricaudet1 and Ulf Pettersson

Department of Microbiology, The University of Uppsala, The Biomedical Center Box 581, S-751 23 Uppsala, Sweden 1Institut Pasteur 28, rue du Dr. Roux, 75724, Paris, France

Received November 20, 1980.

We report the sequence of a 1164 nucleotide long DNA segment, located between map positions 59.5 and 62.8 on the adenovirus type 2 genome. The sequence comprises the 701 nucleotides long 3' non-coding region of the hexon mRNA as well as several important processing signals. The sequence revealed unexpectedly that the 3' non-coding region of the hexon mRNA contains a 609 nucleotide long uninterrupted translational reading frame following a potential initiator AUG. A late 14S mRNA, corresponding to the open reading frame, could be identified by SI nuclease mapping and electronmicroscopy. The mRNA shares a poly(A) addition site with the hexon and pVI mRNAs, and carries a leader sequence which is related, and probably identical, to the tripartite leader, found in late adenovirus mRNAs. The junction between the leader and the body of this novel mRNA is located within the coding part of the hexon gene.

*Present address: The Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA


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